Endocrine Abstracts

The polyglandular autoimmune syndromes (PAS) are rare disorders characterized as multiple autoimmune-mediated organ failure. PAS III includes chronic autoimmune thyroiditis with type 1 diabetes mellitus or pernicious anemia and/or vitiligo or alopecia and many other organ-specific autoimmune diseases, but never involves adrenal cortex. Several patients with PAS III and associated type 1 gastric neuroendocrine tumor (NET) have already been reported. We report probably the first...

68 years old Caucasian women presented to the emergency department (ED) with complains of stiffness, intolerable pain in lumbosacral region and inability to walk for last two days. The common pain-relieving medications did not subdue her pain. The patient had experienced similar episodes for two years, provoked by remaining in fixed position or after having carbohydrate rich meal. Pain usually persisted for a few minutes and symptoms disappeared after light exercise. Her compl...

Acute intermittent porphyria (AIP) is an uncommon monogenic autosomal dominant disorder with a defect in the haem biosynthesis pathway at the level of the enzyme porphobilinogen deaminase. The disease has low penetrance; most patients could stay asymptomatic throughout life. Clinical manifestation depends on various precipitants, which increase hepatic haem production and cytochrome activity. We report a case of a female patient who had regular moderate-to-severe cyclic AIP at...